Get ahead in your research field with ZEISS confocal microscopes

Discover LSM 8 microscopes for fast and gentle live cell imaging

Image the smallest structures, catch the faintest signal, track the fastest processes – or do all of that at once. Get the unique combination of gentle superresolution imaging and high speed with ZEISS LSM 8 confocal microscopes:

Profit from our novel detector design: Airyscan gives you an instant 4 – 8× improvement of signal-to-noise
See the smallest details: Resolve structures of 120 nm (in x,y) and 350 nm (in z)
Track the fastest processes: Acquisition speeds of 27 fps (at 480x480, LSM 880 in Fast mode)
Protect your sample and save time: Acquire the entire fluorescent spectra of all your labels at once

Download our application note "ZEISS LSM 800 and LSM 880 with Airyscan, Imaging Biological Samples – a Reference List" to learn more about how you can profit from Airyscan. See how other researchers have used the unique capabilities of ZEISS confocal microscopes and get inspired!

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Discover how you can profit in your research field

Developmental Biology

Imaging in 3D, multiple colors and over time

Gain 1.7× higher resolution in all three dimensions – resulting in a 5× smaller confocal volume
Use demanding techniques such as spectral imaging and linear unmixing
Save time on investigations into localization and interaction of proteins that require multiple fluorescent labels: collect all these signals in one go
Perform simultaneous spectral detection in a single scan with the highest number of descanned or non descanned channels – including GaAsP technology
Benefit from large fields of view and the highest speed of any linear scanning confocal – up to 27 fps (480x480 pixels, LSM 880 in Fast mode)

Cell Biology

Confocals, your workhorses for 3D imaging

Photo-activatable dyes and fluorescence proteins allow you to measure the dynamics and localization of protein populations over time
Fluorescence correlation studies within cells provide you with valuable information on protein clustering and dynamics
Oversampling with 30 percent longer sampling time
Benefit from faster scan rates and consistent image conditions, guaranteed by ultra-stable laser excitation and Definite Focus
Your FRAP and photoactivation experiments profit from tools for manipulating freely definable ROIs with individual settings

Neuroscience Research

Scaling deep into tissues

Profit from 34-channel parallel imaging across the complete wavelength to monitor up to 10 dyes simultaneously
Combine laser scanning functionality with an outstanding imaging depth thanks to nonlinear optics
Record intact neuronal networks in living animals or thick tissue specimens
To render brain tissue virtually transparent while preserving fluorescent proteins you apply clearing methods such as 'Scale' to your sample
In combination with a range of special clearing objectives, you image to a depth of almost six millimeters within your tissue

See the difference between conventional confocal and ZEISS Airyscan

Confocal

HeLa cells, Actin stained with Phalloidin-Alexa 546, AP3 with Alexa 488

Courtesy of S. Traikov, BIOTEC, TU Dresden, Germany

ZEISS Airyscan

HeLa cells, Actin stained with Phalloidin-Alexa 546, AP3 with Alexa 488

Courtesy of S. Traikov, BIOTEC, TU Dresden, Germany

Confocal

Mouse brain sections of thy1-GFP line imaged using LSM 880, color coded projection

ZEISS Airyscan

Mouse brain sections of thy1-GFP line imaged using LSM 880 with Airyscan, color coded projection

Confocal

B cell Fubulin<488

Joseph Brzostowski, NIH/NIAID, LIG Imaging Facility, Bethesda, MD, USA

ZEISS Airyscan

B cell Fubulin<488

Joseph Brzostowski, NIH/NIAID, LIG Imaging Facility, Bethesda, MD, USA

A cricket embryo - Sample courtesy of: Cassandra Extavour Harvard University UK

Confocal vs. Airyscan

A cricket embryo. This is an egg-stage 22 Gryllus bimaculatus embryo, stained with phalloidin coupled to Alexa488.

Example Airyscan with NLO excitationThis phalloidin stained muscle in the cricket embryo is imaged with NLO laser excitation (900nm). When imaged with a GaAsP NDD the image shows only little detail, while with Airyscan, multiple structures are visible. Even DCV cannot enhance the quality accordingly.

Sample courtesy of: Cassandra Extavour, Harvard University, UK

Tissue cross section stained with Eosin & Hematoxyllin - Olga Chumakova, UTHSCH, Medical School, Houston, TX

Confocal vs. Airyscan

Tissue cross section stained with Eosin & Hematoxyllin. Testis sections from male mice. Imaged with LSM 880 and Airyscan

Olga Chumakova, UTHSCH, Medical School, Houston, TX

Mammary gland transplanted outgrowth - Yang Lu (Daisy), Baylor College of Medicine, Houston, TX

Confocal vs. Airyscan

Mammary gland transplanted outgrowthGFP / RFP / BRDu Stain mammary ductal structures. PFA fixed and paraffin embedded

Yang Lu (Daisy), Baylor College of Medicine, Houston, TX

Confocal

Mouse brain sections of thy1-GFP line imaged using LSM 880, color coded projection

Airyscan

Mouse brain sections of thy1-GFP line imaged using LSM 880, color coded projection

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